姓名

性别

职称

所属教研室

李玉林

男

教授

教育部医用生物材料工程研究中心

E-mail

yulinli@ecust.edu.cn

办公室

实验十五楼-724室

主要研究方向：

长期致力于可吸收医用高分子与医疗器械的应用研究。以第一/通讯作者在Chem. Rev., Adv. Funct. Mater., Biomaterials,ACS Nano等学术刊物发表文章100余篇，申请（授权）发明专利10余项（1项PCT专利）。担任International Journal of Molecular Sciences和Gels等国际SCI学术期刊的客座编辑。承担国家重点研发计划课题1项、国家重点研发计划子课题2项、军委科技委项目、国家自然科学基金面上项目2项、及省部级项目十余项，获上海市人才发展基金和瓯越海智英才计划资助。所开发的可吸收骨钉获得“第二十三届中国国际高新技术成果交易会优秀产品奖”，并入选为“先导技术”榜单（生物医药领域）。

人才培养与国际交流：

担任高材161和材料2002班班导师，指导2项USRP和4项大学生创新项目。分别指导大学生获得第一届上海市大学生生命科学竞赛三等奖、第十三届“华陆科技·奋进杯”大学生课外学术科技作品竞赛二等奖等。自2014年以来指导研究生28名，其中6名硕士研究生（许欣、罗炜、郑玲、张世豪、林安琪、蔡佩昊）获得国家奖学金、1名博士研究生（王宜峰）获校优秀学生称号、4名硕士研究生（郑玲、张世豪、林安琪、蔡佩昊）获得校优秀毕业生称号，7名硕士研究生（王雅琪、郑玲、罗炜、陈璨、许梦瑶、林安琪、蔡佩昊）获校一等奖学金。分别指导研究生获得第三届国际纳米药物大会JACS最佳墙报奖（郑玲）、中国生物材料大会产业化论坛创新创业大赛三等奖、第二届青年学术论文优秀奖评选一等奖（罗炜）、2021生物材料大会优秀墙报奖（蔡佩昊）、2023生物材料大会优秀墙报奖（赵政）。积极参与包括“111”引智计划在内的国际学术交流活动，注重具有国际视野的材料领域年轻人才培养，指导2名学生（刘天舒、陈占立）获得国家奖学金赴澳留学。

主要经历与简历：

近期代表性论文:

1.       生物可吸收高分子基纳米活性材料及植入器械制备技术（课题负责人 / 274.0万元 / 2019-2024）/国家重点研发计划

2.       高品质聚乳酸纤维及其纺织品规模化制备与应用（子课题负责人/ 80.0万元 / 2017-2021）/国家重点研发计划

3.       新型高强度可吸收复合生物活性骨固定器械研发（子课题负责人/ 100.0万元 / 2022-2027）/国家重点研发计划

4.       JG（**急救**技术研究）（主持 / 130.0万元 / 2022-2023）/军委科技委项目

5.       非细胞型活性仿生支架促进老年骨损伤修复应用研究（主持 / 62.0万元 / 2020-2023）/国家自然科学基面上项目

6.       兼具干细胞募集能力和成骨诱导功能的微纳结构活性材料的构建及快速成骨机制研究（主持 / 66.0万元 / 2020-2023）/国家自然科学基面上项目

7.       纳米控释材料开发（主持 / 300.0万元 / 2021-2022）/24848威尼斯—郑州赛科药业科技有限公司技术开发项目

8.       兼具成血管能力的水凝胶联合基因工程化内源性脂肪干细胞治疗脊髓损伤研究（主持 / 40.0万元 / 2018-2021）/上海市科委港澳台科技合作项目

9.       基于微纳结构的高弹高强复合活性骨修复材料的研究（主持 / 10.0万元 / 2015-2017）/上海市国际科技合作基金

10.     强度可控的多级微纳结构活性支架材料与生长因子协同骨修复研究（主持 / 30.0万元 / 2015-2017）/上海市国际科技合作基金

11.     基于3D打印技术构建高强度活性支架材料与生长因子协同骨修复研究（主持 / 10.0万元 / 2015-2017）/上海市人才发展基金

12.     仿生骨多级结构活性支架材料的构建及促进骨组织快速修复的研究（主持 / 16.0万元 / 2017-2018）/教育部基本科研业务费

13.     Self-assembled Nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery（主持 / 15.7万欧 / 2012-2015）/葡萄牙科技部纳米专项

近期代表性论文

1.      Shengyang Liu, Shicheng He, Can Chen, Chunwang Li, Wei Luo, Jing Wang, Hongyan He, Qiang Chen*, Yulin Li*. A versatile disorder-to-order technology to upgrade polymers into high-performance bioinspired materials. Adv. Healthc. Mater. 2023, 12, 2300068. (IF=10.0)

2.      Xiaohuan Yuan, Wei Yang, Yingying Fu, Ziwei Tao, Lan Xiao, Qinzhou Zheng, Dan Wu, Mengya Zhang, Luxin Li, Zhengmao Lu, Yan Wu*, Jie Gao*, Yulin Li*. Four-arm polymer-guided formation of curcumin-loaded flower-like porous microspheres as injectable cell carriers for diabetic wound healing. Adv. Healthc. Mater. 2023, 12, 2301486. (IF=10.0)

3.      Yamin Li, Lan Xiao, Daixu Wei, Shengyang Liu, Yin Xiao, Changsheng Liu*, Yulin Li*, Jinzhong Zhao*. Injectable biomimetic hydrogel guided functional bone regeneration by adapting material degradation to tissue healing. Adv. Funct. Mater. 2023, 34, 2213047. (IF=19.0)

4.      Yulin Li, Yin Xiao, Changsheng Liu*. The horizon of materiobiology: A perspective on material-guided cell behaviors and tissue engineering. Chem. Rev. 2017, 117, 4376. (IF=62.1)

5.        An Chen, Hongwei Lu, Rong Cao, Yi Zhu, Yumeng Li, Renbin Ge, Siruo Zhang, Yulin Li, Lan Xiao, Li Su, Jinhua Zhao*, Honggang Hu*, Zhongling Wang*. A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy[J]. Nano Today, 2022, 45, 101524.(IF=18.7)

6.        Qichen Zhang, Wang Ding, Shenglong Ding, Qingbing Meng, Dihan Su, Taiwei Zhang, Qing Chen, Ruixian Lian, Mingdong Zhao, Baqing Yu, Xilei Li*, Yulin Li*, Li-Bo Jiang*. Robust bioactive protein-based screws with dual crosslinked network for internal bone fixation[J]. Composites Part B-Engineering, 2022, 238,109884. (IF=11.2)

7.        Zhichao Hu, Jiaqi Lu, Annan Hu, Yongjiang Dou, Sheng Wang, Dihan Su, Wang Ding, Ruixian Lian, Shunyi Lu, Lan Xiao, Yu-Lin Li, Jian Dong, Jian Zhou, Xuyong Yang*, Libo Jiang*. Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy[J]. Chemical Engineering Journal, 2022, 4, 137269. (IF=16.4)

8.        Yamin Li, Can Chen, Jia Jiang, Shengyang Liu, Zeren Zhang, Lan Xiao, Ruixian Lian, Lili Sun, Wei Luo, Michael Tim-yun Ong, Wayne Yuk-wai Lee, Yunsu Chen, Jinzhong Zhao*, Changsheng Liu*, Yulin Li*. Bioactive Film-guided Soft–Hard Interface Design Technology for Multi-tissue Integrative Regeneration, Advanced Science, 2022, 9(15), 2105945. (IF=16.9)

9.        Fei Yu, Ruixian Lian, Lu Liu, Ting Liu, Chao Bi, Kan Hong, Shuiquan Zhang, Jiazi Ren, Haikun Wang, Ningjuan Ouyang, Lin-Juan Du, Yuan Liu, Lujun Zhou, Yan Liu, Bing Fang*, Yulin Li*, Sheng-Zhong Duan*, and Lunguo Xia* Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22[J]. ACS Nano, 2022, 16(1), 755-770. (IF=17.7)

10.     Fangxue Zhang, Peng Liu, Wang Ding, Qingbing Meng, Dihan Su, Qichen Zhang, Ruixian Lian, Baoqing Yu, Mingdong Zhao, Jian Dong, Yulin Li*, Li-Bo Jiang. Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 2021, 278, 121169 (IF=15.2)

11.     Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Advanced Science, 2021,8(14),2100165.(IF=16.9)

12.     Kaikai Zheng, Yu Tong, Shihao Zhang, Ruiying He, Lan Xiao, Zoya Iqbal, Yuhong Zhang, Jie Gao*, Lei Zhang, Libo Jiang*, Yulin Li*. Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing. Advanced Functional Materials. 2021, 31(34), 2102599. (IF: IF=19.0)

13.     Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu*, Yulin Li*. Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration. Bioactive Materials, 2021, 6, 3461-3472. (IF=16.8)

14.     Libo Jiang, Shenglong Ding, Wang Ding, Dihan Su, Fangxue Zhang, Taiwei Zhang, Xiaofan Yin, Lan Xiao, Yulin Li*, Fenglai Yuan, Jian Dong. Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration. Chemical Engineering Journal, 2021, 418, 129323.(IF=16.4)

15.     Yulin Li, Yin Xiao, Changsheng Liu*. The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering. Chemical Reviews, 2017, 117(5), 4376−4421. (IF=62.1)

16.     Panpan Yi, Yifeng Wang, Shihao Zhang, Yuan Zhan, Yuhong Zhang, Zhengguang Sun, Yulin Li,* and Peixin He. Stimulative Nanogels with Enhanced Thermosensitivity for Therapeutic Delivery via β-Cyclodextrin-induced Formation of Inclusion Complexes. Carbohydrate Polymers, 2017, 166, 219-227. (IF=10.6)

17.     Guoying Wang, Yaying Chen, Peng Wang, Yifeng Wang, Hua Hong, Yulin Li, Jiangchao Qian, Yuan Yuan, Bo Yu, Changsheng Liu*. Preferential Tumor Accumulation and Desirable Interstitial Penetration of Poly(lactic-co-glycolic acid) Nanoparticles with Dual Coating of Chitosan Oligosaccharide and Polyethylene glycol-poly(D,L-lactic acid). Acta Biomaterialia, 2016, 29, 248–260. (IF=10.5)

18.     Yulin Li*, Dina Maciel, João Rodrigues, Xiangyang Shi, Helena Tomás. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chemical Reviews, 2015, 115(16), 8564-8608. (IF=62.1)

19.     Mara Gonçalves, Priscilla Figueira, Dina Maciel, João Rodrigues, Xue Qu, Changsheng Liu, Helena Tomás, Yulin Li*. pH-sensitive Laponite® /doxorubicin/alginate Nanohybrids with Improved Anticancer Efficacy, Acta Biomaterialia, 2014, 10(1), 300-307. (IF: 10.5)

20.     Yulin Li*, João Rodrigues and Helena Tomás. Injectable and Biodegradable Hydrogels: Gelation, Biodegradation and Biomedical Applications, Chemical Society Reviews, 2012, 41(6), 2193-2221. (IF: 46.2)